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العنوان
Assessment of circulating cell-free DNA 244 levels In Thyroid Cancer /
المؤلف
Mahmoud, Noha Abd El-Halem Aziz.
هيئة الاعداد
باحث / نهى عبدالحليم عزيز محمود
مشرف / عصمت عبدالعزيز عبداللطيف الشرقاوي
مشرف / سحر حسام الحيني
مشرف / علياء محمد منير علي حجازي
الموضوع
Cancer research. Life sciences.
تاريخ النشر
2022.
عدد الصفحات
121 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض الدم
تاريخ الإجازة
1/1/2022
مكان الإجازة
جامعة المنيا - كلية الطب - الباثولوجيا الإكلينيكية
الفهرس
Only 14 pages are availabe for public view

from 122

from 122

Abstract

The study was carried out on 120 subjects who were divided as follow: -
• group (I): 60 patients with a wide range of modules
kinds of thyroid malignancy.
• group (II): 20 patients with fiery thyroid sickness.
• group (III): 20 patients with harmless thyroid growths.
• group (IV) : 20 solid volunteers.
All patients got in Minia University Hospital and Minia Cancer Center.
All patients have experienced a cautious history, including clinical assessment and research facility overviews:
Aroutine:
1. HB, WBC and Tumpplings.
2. Really take a look at liver capacity.
3. Actually look at renal capacity.
4. Pulse glucose.
5. 2HR SP.P.
6. Hdl.
7. LDL.
8. CRP.
9. Testing the thyroid capacity (TSH, Free T3 and Free T4).
10. Against TPO ABS.
11. AntiTG ABS.
BSPECTIAL:
Measurement of CFDNA traffic 244 happens with RTPCR constant quantitative, enhance and evaluate the DNA sections with the recurrent grouping of ALU 244 to augment the affectability of CFDNA as an objective for QPCR.
The aftereffect of this investigation was summed up as follows:
1 There are huge contrasts between four gatherings regarding age and sex (S.001, 0.048), as in the threatening gathering, they have age and a higher fiendishness.
2 There are essentially (p 0.05 worth), the contrast between four gatherings identified with weight, midsection/hip rate, midriff boundary and hip perimeter.
3 is significant (p 0.05), contrasts between research bunches identified with T4 and TSH free of charge.
4 Higher enemy of peroxidase antibodies in the dangerous gathering and lower than in others are the CRP levels higher than the harmful gathering as different gatherings, significantly (p 0.05), the contrast between four gatherings that happen Obtain against thygroglobulin, hostile to peroxidase, and CRP.
5 CFDNA 244 higher in the harmful gathering with exceptionally huge (PValue 0.05), the contrast between four gatherings.
6 The gatherings of gatherings we find that it gave immaterial contrasts between dapilla gatherings, checks and cases regarding a long time and sex.
7 is significant (PValue 0.05), the contrast between the three gatherings identifying with CFDNA 244 is higher in the case bunch than different gatherings.
8 Important variables
About CFDNA 244 mirrors in the threatening gathering are antithucohobulin, against peroxidase. Significant variables at the degree of CFDNA 244 in the gathering of thyroid problems causing irritation are 2 hours BG and hostile to peroxidase. Significant factors on CFDNA 244-Level in the harmless gathering are HDL, TSH, urea, creatinine, S. egg whites what’s more, CRP.