الفهرس 
Introduction and Aim of The WorkOnly 14 pages are availabe for public view
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Abstract
CVDs have maintained the unenviable position as the number one cause of death in the world. In 2019 the number of CVD deaths increased to 17.9 million, which represent 32% of all global deaths. Exposures to environmental pollutants increase risk of heart disease. One of these pollutants is herbicides, that is mostly use is an integral component of modern and improved agriculture. The abuse and misuse of these chemicals lead to significant poisoning worldwide.The present study aimed to assess the protective role of NAC against ATR induced cardiotoxicity in adult male rats.Twenty adult male albino rats, weighing 155±6 g were used in the present study. they were divided into 4 groups 5 animals each. The rats were weighed weekly and divided as follows: Normal control group.N-acetylcysteine treatment group (NAC) receive NAC 200 mg / kg b.w orally day by day for 21 days.Atrazine (ATR) treated group receive ATR orally at a dose of 200 mg / kg b.w for 21 days day by day.N-acetylcysteine and Atrazine treated group, they were received both NAC & ATR of the same dose, route and time as group2 and 3.At the end of the experimental period, rats were fasted overnight, sacrificed under slight halothane anesthesia, blood samples were collected with or without anticoagulant where sera and plasma were separated. Rats were dissected, and the heart were removed, weighed and homogenized at 805 xg, stored at –20oC till used for investigation the selected parameters. The group received only NAC meanly not affected in estimated parameters if compared to that of control. On the other hand, the results recorded in rats purely given ATR showed the following changes: Significant decrease in body weight accompanied by an increase in the relative heart weight when compared to the control.Regarding haematological estimated parameters, there were significant decrease in RBCs, Ht %, platelets, neutrophil and non-significant increase in Hb concentration, while there was a significant increase in WBCs and lymphocyte.Significant increase in the activity of cardiac enzymes markers (LDH and CK-MB) in serum and cardiac tissue.Significant increase in lipid profile concentration (total lipids, cholesterol, and triacylglycerol). A significant increase in the content of oxidative stress marker (MDA, H2O2 and NO) associated with a decrease in the activity of antioxidant enzymes (SOD, CAT, and γ-GT) and non-enzymatic antioxidant (GSH) content in heart tissue.Meanwhile, we notice significant increase in Na+ and K+ concentrations while a significant decrease in Mg2+ concentration.Increase in tumor necrosis factor alpha (TNF-α).On the other hand, the present study demonstrates that, NAC treatment pre-ATR administration partially protect the disturbances in the mentioned parameters, through its free radical scavenging effect, antioxidant property, attenuating lipid metabolism in addition to its anti-inflammatory property.from the obtained data, the results indicate that, treatment of the rats with ATR for 21 days caused disturbance in the estimated cardiac marker leads to their dysfunction.Therefore, this study suggests that NAC may be useful as a protective agent against cardiotoxicity, indicated by the herbicide ATR. This effect can be attributed to their potent antioxidant property and high ability to scavenge reactive oxygen species; as well as its anti-inflammatory property.