الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
CKD and ESRD is a worldwide public health problem and are associated with many complications. CVD is the most common cause of morbidity and mortality among patients with ESRD on HD. Approximately 50% of individuals with ESRD die from a CV cause, an estimated CV mortality that is 15 to 30 times higher in dialysis patients when compared with age- and sex-matched CV mortality in the general population.
HCV infection is a worldwide public health problem and is a common cause for liver fibrosis, cirrhosis, and hepatocellular carcinoma.
Natriuretic peptides are molecules secreted by ventricular musculature in response to volume or pressure overload causing natriuresis, vasodilation, and diuresis, leading to improved myocardial relaxation. NT-ProBNP was found to be elevated in heart failure, renal failure specially ESRD on dialysis and in patients with HCV.
The present study included sixty ESRD patients; group A included 30 HCV positive patients and group B included 30 HCV negative patients aging 18 years old or more who have been assigned to regular long-term HD and perform thrice weekly, four-hour HD sessions for more than 3 months.
All patients included in the study were subjected to: complete history taking and physical examination. Laboratory investigations including complete blood picture, serum urea, serum creatinine, serum calcium, serum phosphorus, serum PTH, total cholesterol, triglycerides, NT-ProBNP, serum total and direct bilirubin, serum albumin, prothrombin time, AST, ALT, HBs Ag, HCV Ab, HIV Ab and HCV PCR. Echocardiography, estimation of Kt/V and calculation of Child-Pugh score for HCV patients.