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Abstract Background & Aim: Colorectal carcinoma is considered the third most commonly detected cancer in males and the second in females. Most colorectal cancers arise from adenomatous polyps that progress from small to large (>1.0 cm) polyps and then to dysplasia and cancer.CRC incidence and mortality rates have been declining in the United States secondary to increased screening mainly through colonoscopy that helps primary prevention and early detection. Polyp detection rate (PDR), is defined as the percent of colonoscopies with one or more polyps detected it has been shown to be highly correlated with adenoma detection rate (ADR).Theminimum standard PDR was estimated at 40%, which corresponds with an ADR of 25%. The aim of this study is to evaluate the polyp detection rate in 2Kasr Al-Ainy3 endoscopy unit and detect the impact of different modalities on it. Methods:This is a prospective randomized study that included 100 Egyptian patients over 50 years old of both genders for whom colonoscopic examination was done with evaluation of degree of bowel preparation, type of agent used for preparation, withdrawal time and polyp detection rate. The candidates divided in 4 groups (control, I-scan, endocuff and underwater colonoscopy groups) Each group contains 25 candidates and PDR evaluated for each group. Results:PDR of all candidates was about 48%. Best results were detected with I-scan utilization giving result of PDR about 56%; it was 52% in underwater endoscopy group and 48% when endocuff was used |