الفهرس 
Prognostic value of day 14 bone marrow morphology in adult AML patients
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Abstract
Background: Acute myeloid leukemia (AML) is characterized by accumulation of immature myeloid cells in bone marrow, resulting in hematopoietic insufficiency, it is the most common acute leukemia in adults with low survival and complete response rates, it is the aim of this study to find the value of early marrow blastic clearance into aiding management options. Objectives: to evaluate the prognostic value of day 14 BMA and effect on DFS and OS. Methods and results: This is a retrospective study that included all patients with proven AML managed in the NCI from January 2010 to December 2014. Through this period, 393 patients were assessed. The median age of the included patients was 34 (ranging from 18 to 67 years) with slight male predominance. 303 patients were statistically analysed, 57.7% had early blastic clearance at day 14, 29.7% had 5% blasts or more on day 14 while 12.5% died early during or shortly after induction. The response rates were different between the groups with 71.4 % in the early responders group and 38.8% in the nonresponders group. Conclusion: There was a significant impact of management decisions taken as a result of day 14 BMA results affecting the DFS and OS, the patients were stratified into risk groups according to cyogenetcs but there was no significant relation with day 14 found