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Abstract This study is an integrated work to test the different factors responsible for aspergillus pathogenicity including source of isolation (medical and environmental) along with some physiological characters as enzymatic activity & haemolysis which are considered virulence factors in many puplications. and then isolates with both highest and lowest enzymatic and haemolytic activity were tested in vivo for pathogenicity in mice and some infection criteria were assessed to relate between enzymatic activity and pathogenicity (CFU in organs, mortality percentage, and mean survival time along with lung histopathological examination). It was found that both medical and environmental isolates can be pathogenic and the pathogenicity order of the isolates agrees with that of their enzymatic activity regardless to the source of their isolation (medical or environmental) which suggests that enzymes (phospholipase, protease, and esterase) can be considered asvirulence factors for Aspergilli |