الفهرس 
Title: Preparation and characterization of lipid based system for topical delivery of antifungal drug
Table of contentsOnly 14 pages are availabe for public view
 |  | from | 213 |  |  |
| | | from | 213 | | |
Abstract
The aim of this work was to increase the solubility of STZ and enhance its permeation and retention in the dermal layers of skin. The work was to prepare 18 systems consisting of oils (Capryol 90, Labrafil M 1944 CS and Peceol), surfactants (Tween® 80 and Cremophor EL) and Transcutol P as a co-surfactant. Pseudoternary phase diagrams were constructed using the water titration method. Thirty six ME formulae loaded with 2% STZ were prepared using oily phase (5, 10, 15 %), surfactant/cosurfactant ratio 55% and water (40, 35, 30 %). The surfactant/cosurfactant ratios ranged from 1:1, 1:2 and 1:3. The drug loaded ME formulae were examined for the thermodynamic stability study. pH of the STZ MEs were found to be 4 {u2013} 6 which was convenient for topical application. The results of MDS and ZP revealed that all formulae were in the ME defined size range. Optimization of the prepared formulae were conducted using Design Expert® program on the basis of minimization MDS and maximization of ZP. F22 [5% PeceolTM, 55% Tween®80: Transcutol®P (1:2), 40% water] and F31 [5% PeceolTM, 55% Cremophor®EL: Transcutol®P (1:2), 40% water] were selected due to their high desirability for ex vivo evaluation. Ex vivo evaluation were carried out for F22 and F33 on the newly born skin mice. F22 showed higher skin retention compared to F31 and the marketed product {u2018}Dermofix®cream{u2019}. A 21 x 31 x 21 x 31 factorial experimental design was used in order to investigate the effect of different type of oils (Capryol and Peceol) , the effect of different concentrations of oil (5% , 10% and 15%), the effect of surfactant type (Tween®80 and Cremophor®EL) and the effect of S/CoS ratios (1:1, 1:2 and 1:3) on particle size and zeta potential of drug-loaded ME using Design Expert®7.0.0 program. TEM was performed to F22 and showed that the globules of the ME were spherical, discrete with uniform droplet size distribution with comparable size to that obtained by photon correlation spectroscopyicle for dermal delivery of STZ