الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, accounting for most cases of dementia among elderly. The pathophysiology of AD involves multiple pathways of neuronal damage, oxidative stress, neuro-inflammation and apoptosis. The amyloid beta peptide (Aβ) plays a central role in the pathophysiology of AD.
Sacubitril/valsartan is now included in guidelines for the management of heart failure (HF). Although it is effective and safe in treatment of HF, there are some concerns regarding the potential long-term adverse effects of chronic neprilysin inhibition on cognitive functions and risk of AD.
In view of this consideration, the present study was designed to investigate the effect of sacubitril/valsartan on cognition in colchicine- and scopolamine- induced AD models in rats. The effect of sacubitril/valsartan was analyzed in comparison to valsartan alone to identify the effect of sacubitril on the development and progression of AD.