الفهرس 
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Abstract
Thyroid hormones are essential for normal basal metabolic rate regulation of all cells, including hepatocytes. The liver plays an important role in maintaining thyroid hormone homeostasis. It synthesizes and secretes the thyroid hormone-binding proteins and it is the principal organ responsible for the conversion of thyroxine (T4) to triiodothyronine (T3), accounting for 80% of the T3 produced daily from T4. Thyroid dysfunction has been reported in several chronic diseases, including liver cirrhosis resulting in the sick euthyroid syndrome, also known as low T3 syndrome (Ghanaei et al., 2012).
Our study was conducted on 93 subjects who were admitted to Zagazig University Hospitals. Their ages ranged from 30 to 78 years with mean age ± SD of 55± 10.68. They were 34 Female (36.6%) and 59 Male (63.4%). All subjects were informed about nature of the study and gave written informed consents. They were grouped clinically into:
group I: included (31) chronic HCV cirrhotic patients with variceal bleeding. Their ages ranged from 44 to 78 years with mean age ± SD of 57± 9.46. They were 9 Female (29%) and 22 Male (71%).
group II: included (31) chronic HCV cirrhotic patients without variceal bleeding. Their ages ranged from 49 to 76 years with mean age ± SD of 62± 6.66. They were 12 Female (38.7%) and 19 Male (61.3%).
group III: included (31) apparently healthy control persons. Their ages ranged from 30 to 63 years with mean age ± SD of 46± 8.67. They were 13 Female (41.9%) and 18 Male (58.1%).
The results of the study can be summarized as follows;
1- There were high statistically significant differences between group I compared with group III and group II compared with group III as regards Hb, PLT, INR, Albumin, and Bilirubin. There were no statistically significant differences between group I compared with group II as regards Hb, INR, Albumin, and Bilirubin. However, there were statistically significant differences between group I compared with group II as regards PLT.
2- There were high statistically significant differences between group I compared with group III, and group II compared with group III as regards FT3. There were no statistically significant differences between the studied groups as regards FT4 and TSH.
3- There were high statistically significant differences between studied groups as regards spleen size and PV diameter.
4- There were statistically significant differences between OV grade 3 and 4 and other grades of OV as regards FT3, PLT, INR, Spleen Size, and PV diameter in group I. In addition to statistically significant differences between OV grade 3 other grades of OV as regards FT3, PLT, INR, Spleen Size, and PV diameter in group II.
5- There were no statistically significant differences between Child score, and TSH and FT4. While, there were statistically significant differences between Child score C and other Child score (A, B) as regards FT3 in both group I and II.
6- In both group I and II, There were statistically significant negative correlations between OV, Child Score and FT3. In addition, there were statistically significant negative correlations between FT3, PLT and oesophageal varices grades. Also, statistically significant positive correlations between INR, spleen size, PV diameter, Child score and oesophageal varices grades were recorded.