الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
In conclusion, we have demonstrated that MA extracts induce DNA damage in BC cells followed by apoptosis via p38 and ERK1/2 MAPKs signaling. This DNA damaging effect is due to TOP1 inhibition. These results indicate that MA is a potential therapeutic agent for further development of drug/s for the management of breast cancer. Although, to our knowledge this study is the first study to evaluate the effect of Medemia argun extract in mammalian cancer cells, this warrants further investigation to introduce the effective individual compound/s working as TOP1 inhibitor/s. Such studies may reveal further mechanisms by which cells response to MA extract in breast or other cancers.
In our study we give a good evidence for that, in case of cell viability, we noted that MA crude ethanolic extract can inhibit MCF-7 proliferation and alter cell morphology in a dose dependent manner. Also, we noted that MA fraction inhibit colony formation of MCF-7 cells.