الفهرس 
Title : Histological and histochemical study on the pregnant albino rats and their fetuses
AbstractOnly 14 pages are availabe for public view
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Abstract
This study was undertaken to evaluate the teratogenic effects of the proton pump inhibitor (PPI) drug (pantoprazole) which was on a daily basis orally-administered to the pregnant albino rats (Rattus norvegicus). The virgin female rats were mated with the male rats and the pregnant rats were orally-administered a human equivalent dose (4.11 mg/kg) of Pantoprazole from 6th to 19th gestation days. On the 02th day of gestation, female rats were sacrificed and fetuses were removed from the uterus and evaluated for mortality rate, growth parameters, morphological and skeletal malformation as well as histological and histochemical studies of placentae and livers of mothers and livers of fetuses. In addition, the oxidative stress markers were evaluated. Results showed decreased weight gain of pregnant rats and also fetal growth retardation that were dose-dependent during gestation period. Hematomas were detected morphologically in the fetuses and high incidence of resorption in treated animals. Fetal skeletal anomalies summarized as less degree of ossification in most bones, costal separation, curved and wavy ribs. In addition, the pantoprazole induced histopathological changes in placenta and also livers of both the mother rats and their fetuses. Biochemical studies in both pregnant rats and their fetuses showed that pantoprazole induced a reduction in the level of reduced glutathione (GSH) which is an important intracellular (non-enzymatic antioxidant), superoxide dismutase (SOD) (enzymatic antioxidant) compared to control group