الفهرس 
Title :Synthesis and antitumor evaluation of heterocyclic compounds synthesized from B-diketone and cyanomethylene reagents
AbstractOnly 14 pages are availabe for public view
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Abstract
The reaction of ethyl benzoyl acetate with malononitrile in an oil bath at 120{u00B0}C gave the condensation product 3. The latter compound underwent a series of heterocyclization to give thiophene, thiazole, pyridine and pyras derivatives. The structures of the synthesized products were established on the basis of analytical and spectral data. The antitumor evaluation of the newly synthesized products against the six cancer cell lines namely human gastric cancer (NUGC and HR), human colon cancer (DLDI), human liver cancer (HA22) and (HEPG2), human breast cancer (MCF), nasopharyngeal carcinoma (HONET) and normal fibroblast cells (w138) indicated that many compounds expressed high inhibition against the cancer cell lines. Compounds 3, 7a, 7e, 11b,13e, 13d, 16a,16b, 18a, 20a and 25b were the most cytotoxie compounds among the tested compouds