الفهرس 
Title : Relation of serum vitamin D and vitamin D receptor polymorphisms to idiopathic parkinson disease
AbstractOnly 14 pages are availabe for public view
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Abstract
Background: Vitamin D is suggested to play an important role in neurodegenerative disorders. Accumulating data have provided suggestions that vitamin D receptor (VDR) gene is a candidate gene for susceptibility to parkinson disease (PD). Objective: This study aimed to assess the relation between serum 25 Vitamin D3 and VDR gene polymorphisms to idiopathic PD, and whether they have an impact on clinical presentation or disease severity. Subjects and methods: One hundred subjects were included in the study; fifty patients suffering from idiopathic PD and fifty age and sex matched healthy control subjects. Patients were subjected to complete clinical assessment and the severity of PD was evaluated using unified parkinson disease rating scale (UPDRS). Measurement of serum 25 vitamin D3 using Enzyme Linked Immuno Sorbent Assay (ELISA) and genetic testing for VDR gene single nucleotide polymorphisms (FokI and ApaI) using real time polymerase chain reaction (PCR) technique were done for both patients and controls. Results: Serum 25 vitamin D3 was significantly lower in PD patients compared to healthy controls (P=0.029). Distribution of vitamin D receptor gene polymorphisms (FokI and ApaI) was insignificantly different between PD patients and controls. However, there was a statistically significant difference between VDR gene ApaI polymorphisms regarding mean age and age of disease onset (p= 0.005 and 0.012 respectively). AC genotype was associated with younger age and younger age at onset of disease compared to CC and AA genotypes. Also, there was a tendency towards significant preponderance of male sex in the GG genotype of fokI gene polymorphisms P=0.06