الفهرس 
Title : Application of nanotechnology in cancer radiation therapy
AbstractOnly 14 pages are availabe for public view
 |  | from | 159 |  |  |
| | | from | 159 | | |
Abstract
Over the last decade, chemo-radiotherapy represented a well-established paradigm for cancer treatment. Developing new strategies to promote the therapeutic efficacy while reducing toxic side effects of chemo-radiotherapy is a main research objective in cancer therapy. A promising new oncological strategy for enhancing chemo-radiotherapy against cancer involves the utilization of multifunctional nanoparticles (nanocarriers and radiosensitizers). This work aimed to introduce multifunctional gold ganoparticles (GNPs) formulations with different surface coatings and assess their abilities in the enhancement of chemo-radiotherapy. For this purpose, chitosan capped gold Nanoparticles (CS-GNPs) and mesoporous silica-capped gold Nanoparticles (MS-GNPs) were synthesized and characterized using UV/Vis absorption spectroscopy, transmission electron microscopy (TEM), Dynamic Light scattering (DLS), zeta potential measurements and Energy Dispersive X-ray Analysis (EDXA). The prepared multifunctional nano-formulations acted as nano-radiosensitizers, in addition to being intrinsic drug delivery systems, allowing efficient loading and targeting of chemo-therapeutics such as doxorubicin (DOX). DOX-loaded CS-GNPS (CS-GNPs-DOX) and DOX-loaded MS-GNPs (MS-GNPs-DOX) were prepared and their drug encapsulation efficiencies were 20% and 22%, respectively. The therapeutic efficacy of CS-GNPs-DOX and MS-GNPs-DOX against breast cancer cells (MCF-7) were studied individually. Breast cancer cells were irradiated with different doses of X-rays (0.5, 1 and 3 Gy) after the application of the synthesized nano-radiosensitizers loaded with drug, and then the effect of the combined therapy was assessed via neutral red cell viability assay