الفهرس 
Biological evaluation of Interleukines 2 , 12 and taurine combination against human hepatoma cells propagated ex-vivo
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Abstract
Hepatocellular carcinoma (HCC) is the sixth most prevalent malignancy worldwide and is a rising cause of cancer related mortality. Therefore, it is important to search for agents that have a potential anticancer effect against HCC. The objective of the present study was to investigate the anti-cancer effects of interlekin-2 (IL-2), IL-12 and taurine in human hepatocellular carcinoma cells (Hep-G2). HepG2 cells was obtained from the National Cancer Institute and cultured in RPMI medium. Cells were classified into 6 groups, HepG2 cells without treatment as control group (group A), HepG2 cells treated with IL-2 (group B), HepG2 cells treated with IL-12 (group C), HepG2 cells treated with taurine (group D), HepG2 cells treated with IL-2 and IL-12 (group E) and HepG2 cells treated with IL-2, IL-12 and Taurine (group F). Viability of HepG2 cells was evaluated using MTT assay. group B, E and F were significantly different from the control group with decreased viability in contrast to group C and D. LDH release assay was used to measure cytotoxicity of the previously mentioned natural agents. There was no significant difference between group D and the control group, while apparent cytotoxicity was observed in group B, C, E and F