الفهرس 
Utility of Active Methylene Reagents as Precursors for Synthesis of New Heterocycles
AbstractOnly 14 pages are availabe for public view
 |  | from | 242 |  |  |
| | | from | 242 | | |
Abstract
The thesis is composed of three main original parts. In part I, novel pyrazolo[l,5- a]pyridine derivatives containing (3-oxocyclohex-1-enyl)amino group at position 2 were synthesized in good yields using simple and efficient methodology. In part II, an efficient synthesis of novel bis-pyrazolo[l,5-a]pyridine derivatives through Michael addition reaction of 3-amino-5-cyanomethylpyrazole-4-carbonitrile with bis-arylidenemalononitrile is reported. In part III, a concise and efficient approach to tetrakis(uracil) derivatives by the reaction of bis(aldehydes) with four equivalents of 6-aminouracil is reported. Also, the synthesis of bis(pyrimido[4,5-b]quinolones) and bis(indeno[2’,1’:5,6]pyrido[2,3-d]pyrimidine) derivatives has been accomplished by a three-component reaction involving bis(aldehydes), 6-aminouracil and the appropriate cyclic-1,3-dione. The method involves domino Knoevenagel condensation/Michael addition reaction. All new compounds are characterized by different spectral tools