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Abstract Aim of Work: To detect the effect of Yellow Micropulse Laser 577-nm vs Infrared Diode Micropulse Laser 810-nm in the treatment of Diabetic Macular Edema. Methods: One eye of the same patient (randomly selected) will undergo laser treatment with Yellow Micropulse Laser 577-nm and the other eye (randomly selected) with Diode Micropulse Laser 810-nm. Results: In the right eye, Pre laser examination showed that the median of the central macular thickness presented in the OCT was 311 and the range of central foveal thickness varied between 198 {u2013} 1430. Post laser at 3 months examination showed that the median of the central macular thickness presented in the OCT was 250 and 348 in the left eye and the range of central foveal thickness varied between 175 {u2013} 1200. In comparison to the left eye where, pre laser examination showed that the median of the central macular thickness presented in the OCT was 358 and the range of central foveal thickness varied between 198 {u2013} 1140 |