الفهرس 
Title: Evaluating galectin-3 (LGALS3) +191 gene variant and serum galectin-3 levels in Egyptian children with familial mediterranean fever
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Abstract
Background:The most important and devastating complications of Familial Mediterranean fever (FMF) is renal amyloidosis, usually affecting the kidneys leading to end stage renal failure. FMF- related renal amyloidosis needed to be diagnosed early. Optimal colchicine dose is effective in prevention and reversing renal amyloidosis. Galectin-3 is a Ý-galactoside-binding lectin, which regulate cell-cell and extracellular interactions during self /non-self-antigen recognition and cellular activation, proliferation, differentiation, migration and apoptosis.It plays a significant role in the inflammatory response, the immune response and tissue fibrosis. The aim of the study isto evaluate serum galectin-3 level and its gene polymorphism (LGALS3 191 C>A) as a marker of proteinuria and subclinical inflammation in Egyptian children and adolescents with FMF. Methods: Fifty FMF patients in attack free period and 40 healthy children were included as a control group. Serum levels of galectin-3 were measured, Galectin-3 (LGALS3) c.191 C>A (rs4644) gene variant was investigated and morning spot urine was collected for determination of Albumin / Creatinine Ratio (ACR)