الفهرس 
Value of transcranial direct current polarisation in intractable focal epilepsy patients
LIST OF CONTENTSOnly 14 pages are availabe for public view
 |  | from | 127 |  |  |
| | | from | 127 | | |
Abstract
BackgroundEpileptic seizures are resistant to pharmacotherapy in approximately 1/3 of all instances, a statistic that has not changed despite the introduction of >20 new antiepileptic drugs in the late twentieth and early twenty-first century. Accordingly, neuromodulation protocols are emerging as potentially valuable tools for seizure control. In focal epilepsy, the capacity of cathodal transcranial direct current polarisation to reduce cortical excitability has prompted research into this technique{u2019}s antiepileptic potential. PurposeTo investigate whether cathodal transcranial direct current polarisation can modify seizure frequency in drug resistant focal epilepsy patients assessed by clinical evaluation, seizure diary and electroencephalography. Methods: A randomized, double blind, placebo controlled clinical trial on 20 patients diagnosed with multidrug resistant focal epilepsy were enrolled in our study. The patients were randomized into 2 groups. group A received real 5-day sessions of cathodal tDCS over the area of most frequent interictal epileptiform discharges or the area of suspected ictal onset inferred by MRI findings, ictal EEG and clinical seizure semiology. group B received sham sessions. Outcome indicators were baseline and post sessions seizure diary as well as EEG (epileptiform discharges were counted per hour)