الفهرس 
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Abstract
Our work focused on the synthesis of novel 1,3,4-thiadiazole derivatives incorporating piperazine moiety to explore their biological activities resulting in efficient bio molecules with minimum side effects.The reaction of piperazine 1 with two molar amount of carbon disulfide in the presence of triethyl amine lead to the formation of piperazine-1,4-bis(dithiocarbomate salt) 180 in a very good yield (87%), Scheme 31. The nucleophilic substitution reaction of methyl and ethyl iodides via the sulfur anion of salt 180 produced the substitution products 181a,b in an excellent yield. Another nucleophilic substitution of the products 181a,b using hydrazine hydrate as a nuccleophile in ethanol as a solvent afforded the titled compound in a good yield 182 (70%). Condensation of bis(carbthiohydrzide) derivative 182 with p-nitrobenzaldehyde furnished 1,4-bis(4-nitrobenzylidene)piperazine-1,4-bis(carbothiohydrazide) 183 in a low yield (52%), Scheme 31.