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Abstract Background: The extra skeletal effects of vitamin D have raised considerable interest. Vitamin D defi»ciency appears to be related to the development of diabetes mellitus type 2. Vitamin D may affect glucose homeostasis. We aim to screen for vitamin D deficiency in type 2 diabetic patients and healthy controls and to examine whether 25-hydroxyvitamin D (25 OHD) has clinically significant influence on hemoglobin glycation (HbA1c) and Albumin /Creatinine Ratio in T2DM subjects. Methods: Present study was carried out in 82 subjects (41 T2DM cases and 41 non-diabetic controls), Glycosylated hemoglobin (HbA1c) and 25(OH)D3 levels were measured in both groups and A/C ratio measured in T2DM cases. Results: Low vitamin D levels were seen in 65.5% and 56.1% of T2DM cases and control subjects respectively (p value 0.062). 25(OH)D3 levels were found to be inversely associated with HbA1c levels in the diabetic patients (p value 0.000 & r -0.482). Significant correlation between Vitamin D level in diabetic cases and their A/C Ratio ( p value 0.01 & r -0.396). Conclusion: vitamin D levels appeared to be lower in diabetes mellitus type 2 patients than in the control group with no significant difference, vitamin D levels being related to glycemic control in diabetes mellitus type 2. There is significant correlation between vitamin D and A/C ratio in diabetic patients |