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العنوان
Formulation of non steroidal anti-inflammatory drug in topical dosage form /
الناشر
Dina Ahmed Mostafa Shaaban ,
المؤلف
Dina Ahmed Mostafa Shaaban
هيئة الاعداد
باحث / Dina Ahmed Mostafa Shaaban
مشرف / Alia Badawi
مشرف / Doaa Ahmed Elsetouhy
مشرف / Boushra Mohamed Elhoussieny
تاريخ النشر
2018
عدد الصفحات
129 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
العلوم الصيدلية
تاريخ الإجازة
21/1/2019
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Pharmaceutics
الفهرس
Only 14 pages are availabe for public view

from 157

from 157

Abstract

Non-steroidal anti-inflammatory drugs are widely used for treatment of pain and inflammation, all classic NSAIDs inhibit COX-1 and COX-2, causing undesirable side effects such as gastric ulceration, altering platelet function and renal toxicity. Topical drug delivery systems are attractive routes for administration of NSAIDs, as they overcome gastrointestinal side effects and give local therapeutic effect. Lornoxicam, the drug of choice in this study, is a potent NSAID that belong to oxicams, it has short half-life, which require repeated uptake. In addition, lornoxicam has poor aqueous solubility leading to poor bioavailability