الفهرس 
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Abstract
Attention-deficit hyperactivity disorder has higher incidence rate than other neurodevelopmental disorders. ADHD is characterized by inappropriate levels of inattention, hyperactivity, and impulsivity. These patients must have evident social and academic problems that affect their global performance. It is proposed that ADHD is occurring from multiple etiologies, perhaps genetics, biological and psychosocial motivates.
The ADHD-specific scales are designed to focus on ADHD symptoms and can determine the presence of core symptoms of ADHD as defined by DSM-5 criteria for ADHD. Dopamine beta hydroxylase is a synthetic enzyme for nore-epinephrine. Knocking out the DBH gene led to decreased NE levels in central neural system, which suggested the important role of this enzyme in the maintenance of normal NE functions.
The aim of the current study was to assess the possible association between dopamine beta-hydroxylase gene polymorphism and ADHD in affected children as well as follow up for one year after pharmacological management using Vanderbilt scale.
Study groups:
This study was conducted on 160 children, divided into two groups :
group I (ADHD): including 80 children (48 males, 32 females) with the diagnosis of ADHD, their age ranges from 6 to 14 years.
group II (control group): including 80 healthy children (45 males, 35 females) of matched age and sex their age ranges from 7 to 13 years.
The patients were randomly selected from those attending at the pediatric neuropsychiatry outpatient clinic at the pediatric department of Menoufia University hospital in the period from May 2020 to May 2021after taking consent from caregivers.