الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Studies have shown increase evidence to suggest a significant association between environmental exposure to some agricultural pesticides and adverse developmental outcomes in women. Imidacloprid, is an neonicotinoids insecticides recommended globally and in Egypt to control various pests, was evaluated for potential developmental
toxicity on the critical gestation periods.
The aim of this study was to confirm or not the hypothesis that there is a relationship between the critical gestational periods and the adverse effects of IMI comparing with
non-pregnant mice..
The study was conducted on 440 of female and 220 of male CD1- mice in 12-14 weeks
of age and brought from Faculty of Science, Alexandria University. The experimental protocol was approved by Alexandria University Animal Ethics Committee (AUAEC) through the experimental steps, animals divided into nine groups.
group one was treated with Imidacloprid at doses 10,15and 20mg/kg/day on gastetional day 8 and Cesarean Section was occurred on Day 18 of gestation. Second group was treated with Imidacloprid at doses 10,15and 20mg/kg/day on gastetional day 10 and
cesarean section was occurred on Day 18 of gestation. group three was treated with Imidacloprid at doses 10,15and 20mg/kg/day on gastetional day 12 and cesarean section was occurred on Day 18 of gestation. group four was treated with Imidacloprid at doses 10,15and 20mg/kg/day on gastetional day 14 and cesarean section was occurred on Day
18 of gestation. The fifth group was treated with Imidacloprid at doses 10,15and 20mg/kg/day on gastetional day 8-15 and cesarean section was occurred on Day 18 of gestation. group six was treated with Imidacloprid at doses 10,15and 20mg/kg/day on gastetional day 10-15 and cesarean section was occurred on Day 18 of gestation. group
seven was treated with Imidacloprid at doses 10,15and 20mg/kg/day on gastetional day 12-15 and cesarean section was occurred on Day 18 of gestation. group eight was
treated with Imidacloprid at doses 10,15and 20mg/kg/day on gastetional day 14-15 and cesarean section was occurred on Day 18 of gestation. The last group was treated with Imidacloprid at doses 10,15and 20mg/kg/day on gastetional day 6-15, and cesarean section was occurred on Day 18 of gestation. Each group included 40 pregnant mice expel last group including 120 pregnant mice.
The results of the previous treatments showed that:
Results obtained from this study confirmed our hypothesis that: there is a relationship between doses of imidacloprid and different periods of gestation. By increasing the exposure duration, the effects of imidacloprid increase regarding the maternal and fetuses’ parameters.