الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Chronic kidney disease is a global public health concern. The thesis was designed to study the effect of bone marrow mesenchymal stem cells (BMSCs) and Hyaluronic acid (HA) on chronic kidney disease in rat model. Our results showed the effect of HA on the viability of BMSCs. Furthermore, preconditioning cells with HA could ameliorate the symptoms of Adriamycin induced chronic kidney disease in rats. This improvement was detected by remodeling the antioxidant activities, reducing the fibrosis and apoptosis induced by Adriamycin. Hence, HA might have acrucial role in the enrollment of injected mesenchymal stem cells to the injured renal tissues.