الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 89 |  |  |
| | | from | 89 | | |
Abstract
Background/Aims: Esophageal motility disorders (EMD) are the main etiology of non-obstructive dysphagia (NOD), but they are underestimated in Egypt. High-resolution manometry (HRM) with Chicago classification version 3.0 (CC v3.0) is the current gold standard diagnostic modality to assess EMD in patients with NOD. In this HRM-based study, we aimed to classify EMD among Egyptian patients and explore the relation between the severity of symptoms and the various groups of EMD.
Methods: from January 2020 to January 2021, patients with dysphagia were subjected to diagnostic work up which included symptom questionnaire for Eckardt score, esophagogastroduodenoscopy, barium esophagogram, and HRM. All patients were categorized based on the HRM results using CC v3.0 after exclusion of those with obstructive esophageal lesions.
Results: Out of 252 patients with dysphagia, 55 patients with NOD were analyzed according to CC v 3.0. Achalasia was diagnosed in 31 (56.4%) patients (type I: 18 [58.06%]; type II: 9 [29.03%], and type III: 4 [12.9%]), 3 (5.5%) patients with esophagogastric junction outflow obstruction, 2 (3.6%) patients with absent contractility, 4 (7.3%) patients with distal esophageal spasm, 7 (12.7%) patients with ineffective esophageal motility. 8 (14.5%) patients with normal manometry. Patients with achalasia experienced significantly high regurgitation (96.8% vs 70.8% p=0.016) compared with those without achalasia.
Conclusions: Achalasia was the most common EMD in Egyptian patients with NOD. Eckardt score was higher in patients with outflow obstruction and major motor disorder, but it could not differentiate different categories of CC of EMD. HRM is effective in characterization of EMD.