الفهرس 
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Abstract
This study assessed the possible molecular mechanism through which Moringa Oleifera leaves alcoholic extracts (MOLAE) exerts its anti-obesity activity. Fiftysix male Wister albino rats were allocated into seven groups. Control group was fed an ordinary standard diet. The second group was fed a standard diet and was given MOLAE orally at a dose of 400 mg/kg bwt. The third group was fed a high fat diet (HFD) for 12 weeks. The fourth and fifth groups were fed HFD and administered MOLAE orally at doses of 200 and 400 mg/kg bwt, respectively for 12 weeks. Six and seven groups were fed HFD for 8 weeks then administered MOLAE at doses 200 and 400 mg/kg bwt orally, respectively and were fed ordinary standard diet for another 4 weeks. Supplementation of rats with HFD significantly increased food intake, body, liver and visceral fat weights, serum ALT and AST activities, serum levels of triglyceride, total cholesterol, LDL, VLDL and Non–HDL, atherogenic indices, and mRNA expression of sterol regulatory element binding protein 1c (SREBP-1c), sterol regulatory element binding protein 2 (SREBP-2), hydroxy methyl glutaryl Co enzyme A reductase (HMG-COAR) and hormone sensitive lipase (HSL) in hepatic tissue. While it significantly decreased serum level of HDL. On the contrast, administration of HFD fed rats MOLAE significantly reduced , food intake, body, liver and fat weights, serum ALT and AST activities, serum level of triglyceride, total cholesterol, LDL, VLDL and Non–HDL, atherogenic indices and mRNA expression
of SREBP-1c, SREBP-2, HMG-COAR and HSL in hepatic tissue .However, it increased serum level of HDL. These results indicated that MOLAE was a potent antiobesity and anti-atherogenic agent via controlling the lipogenesis and cholestrogenic genes expression in liver. Keywords: HFD, Moringa oleifera, SREBP-1c, SREBP-2, HMG-COAR, HSL