الفهرس 
C ORONA V IRUSOnly 14 pages are availabe for public view
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Abstract
Background: COVID-19 is an infectious disease caused by severe acute respiratory syndrome coronavirus. Corona virus affects the central nervous system in various different ways either through a retrograde transfer via the olfactory epithelium or through the cribriform bone and reaches the brain directly in seven days’ time or due to disruption of blood brain barrier which occurs during the viremia phase of illness and the virus will enter the brain directly. Another postulated mechanism is the invasion of peripheral nerve terminals by COVID-19 which then gains entry to the CNS through the synapse connected route.
Objective: To determine the prevalence of neurological symptoms and complications in COVID-19 patients and if we can use the neurological symptoms and its relevance as prognostic factors for disease severity.
Patients and Methods: This was a cross sectional study that was conducted on COVID-19 positive patients admitted to isolation ICU Ain Shams University Hospital through 4 months.
Results: The present study aimed to provide a comprehensive overview of neurologic manifestations associated with SARS-CoV-2 infection and to describe the clinical course and outcomes of COVID-19 patients with neurologic manifestations. Our results highlight the broad spectrum of neurological manifestations associated with SARS-CoV-2 infection: the majority of neurologic manifestations were altered mental status (27.7%), anosmia (13.8%) followed by headache (12.5%).
Conclusion: the neurological manifestations are common in Covid-19 patients. There is an association between the presence of neurological manifestations and mortality.