الفهرس 
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Abstract
Hepatotoxicity is defined as injury or liver damage caused by exposure to
drugs or other nonpharmacological agents. There is a wide spectrum of
symptoms ranging from mild non-specific symptoms like asymptomatic
transaminitis, acute hepatitis, chronic hepatitis and cholestasis to liver failure.
There are many classes of drugs causing drug-induced liver injury
including NSAIDs, anti-infective drugs, anti-cancer drugs, hormonal drugs,
immunosuppressive agents, sedative and neuropsychiatric drugs.
Bisphenol A is a high-production volume industrial chemical found in
many consumer products. It induces oxidative stress and partial fat infiltration
and inhibits cytochrome P450 isoforms in the liver of rats. The developmental
exposure to BPA causes liver diseases, including hepatic steatosis, liver tumours
and metabolic syndrome.
Moringa oleifera belongs to the family moringaceae, is a small or middle
sized tree, usualy grows 10-12 m in height. The extracts of leaves, seed and pod,
have potent antidiabetic activity. Moringa ameliorated liver fibrosis in rats and
reduces liver damage and symptoms of liver fibrosis, decreased the CCl4-
induced elevation of serum aminotransferase activities and globulin level, and
reduced the elevated hepatic hydroxyproline content and myeloperoxidase
activity.
The aim of this study was to evaluate the effect of M. oleifera leaves
extract against BPA induced hepatic toxicity in rats.
Results of the present study showed that:
? There were significantly higher serum levels of AST, ALT, blood sugar,
MDA, TNF-?, MIF and significantly decreased serum levels of GSH in
rats received BPA when compared to control group so, BPA lead to liver
toxicity.
? There were significantly reduced serum activities of AST, ALT, blood
sugar, MDA, TNF-? and MIF levels in rats received BPA with M.
oleifera leaves extract at dose 200,400 mg/kg BW while, there were non
significantly, significantly increased serum levels of GSH, respectively
compared to rats toxicated by BPA.
? There were significantly reduced serum activities of AST, ALT and blood
sugar levels while there were non significantly, significantly reduced
serum levels of MDA, respectively in rats received M. oleifera leaves
extract at dose 200,400 mg/kg BW for one month then toxicated with
BPA compared to rats toxicated by BPA.
? There were non significantly, significantly increased serum level of GSH,
respectively in rats received M. oleifera leaves extract at dose 200,400
mg/kg BW for one month then toxicated with BPA compared to rats
toxicated by BPA.
? There were significantly reduced serum levels of TNF-? and non
significantly reduced serum levels of MIF in rats received M. oleifera
leaves extract at dose 200 mg/kg BW for one month then toxicated with
BPA compared to rats toxicated by BPA.
? There were significantly reduced serum levels of TNF-? and MIF in rats
received M. oleifera leaves extract at dose 400 mg/kg BW for one month
then toxicated with BPA compared to rats toxicated by BPA