الفهرس 
ASSISTED REPRODUCTIVE TECHNOLOGY (ART)Only 14 pages are availabe for public view
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Abstract
Background: Although CA-125 is a well-established ovarian tumour marker, this glycoprotein is also produced
by the endometrium of naturally ovulating women, and is measurable in the peripheral circulation. Therefore, CA125 can be regarded as an indicator of endometrial receptivity and a predictor of pregnancy.
Aim of the Work: it is to assess the relationship between serum CA-125 concentrations & prediction of
pregnancy in intracytoplasmic sperm injection (ICSI) cycles.
Patients and Methods: This was a prospective observational cohort study, which was conducted at Assisted
Reproductive Technology Unit (ART Unit) at Ain Shams University Maternity Hospitals on 75 Women who
underwent intracytoplasmic sperm injection (ICSI). The study started on May 2021 & ended on March 2022. This
study included women between 18 and 35 years old with indication for ICSI & their ovaries or uterus were free
from any abnormalities & any pathological findings were excluded. Blood samples were taken from each patient
and on the day of oocyte retrieval, for measurement of serum CA-125 concentrations. Primary outcome was
Occurrence of pregnancy (chemical). Secondary outcome was assessment of relationship between serum CA125,
oocyte maturation & embryo quality.
Results: The number of produced embryos and number of Class A embryos were significantly higher in
pregnant women (p value <0.05). CA 125 has poor predictive value with an area under the ROC curve
(AUC) of 0.531. Best cut-off criterion is CA 125 value >16.7 IU/ml which has sensitivity of 48.7% and
specificity of 73.7%. After adjustment for E2 level, AMH level, number of M2 oocytes and number of class
A embryos, CA 125 had no statistically significant association with pregnancy (p value >0.05). There is
weak positive correlation between CA 125 and abnormal oocyte count (p value <0.05).
Conclusion: the measurement of CA 125 on day of the oocyte retrieval is not predictive of subsequent
pregnancy as there was no statistically significant difference between pregnant & non-pregnant groups as
regard CA 125 & there is only weak positive correlation between CA 125 and abnormal oocyte count.
Therefore, determination of CA 125 doesn’t appear to be useful in predicting the outcome of ICSI cycles.