الفهرس | Only 14 pages are availabe for public view |
Abstract The aim of this study was to evaluate the role of serum and CSF heparin binding protein in early diagnosis of acute bacterial meningitis and its efficacy in differentiating acute bacterial from non-bacterial meningitis. This study was conducted on 133 subjects included 65 patients with acute bacterial meningitis, 48 patients with acute non bacterial meningitis and 20 healthy persons of matched age and sex as controls. Patients and controls were selected from inpatients and outpatients clinic of Menouf Fever hospital in the period between January 2020 and April 2021. Patients were 58 (51.3%) males and 55 (48.7%) females and controls were 8 (40%) males and 12 (60%) females, their ages were ranging between 17-74years old. An informed consent was obtained before patients entered the study. Patients and controls were classified into the following groups:- group 1: 65 patients with acute bacterial meningitis. Group2: 48 patients with acute non-bacterial meningitis. Group3: 20 volunteer subjects receiving spinal anesthesia for any cause other than CNS as a control group. Inclusion criteria: patients with suspected acute meningitis. Exclusion criteria: Infections other than meningitis (UTI or chest infection), patient receiving antibiotics more than 48 hours and any CNS diseases except meningitis e.g (Cerebral haemorrhage or Post trauma or stroke). All patients were subjected to the following: Full history taking, full general and neurological clinical examination and investigations including: Complete blood count, erythrocyte sedimentation rate, C reactive protein, liver profile, kidney function testes ,serum Na and K, blood glucose level , urine analysis and chest x ray. CSF examination for Chemical in the form of glucose, protein and lactate levels. Microbiological in the form of culture for detection of bacteria. Cytological examination in the form of: Total and differential WBCs count. Heparin binding protein was done both in serum and CSF at the same time to all groups using Enzyme linked immunosorbant assay . |