الفهرس 
Introduction and Aim of the workOnly 14 pages are availabe for public view
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Abstract
Preeclampsia (PE) is a pregnancy-specific condition that increases maternal and infant mortality and morbidity. It is clinically characterized by high blood pressure after 20 weeks of gestation. This condition may also present with a triad of signs including hemolysis, elevated liver enzymes, and low platelet count, known as HELLP syndrome. Preeclampsia occurs in an estimated one in 20 pregnancies. It can develop into eclampsia, or convulsive fits, which account for up to 10 percent of maternal deaths. from another public health perspective, it is alarming that the rate of preeclampsia has increased in worldwide especially in developed countries due to an increase in number of older mothers and multiple births, conditions known to increase the risk of preeclampsia. The study of risk factors and the underlying evidence base can be used to assess risk at antenatal booking so that a suitable surveillance routine to detect preeclampsia can be planned for the rest of the pregnancy. The knowledge of the most important risk factors in the population could be useful for the clinicians to pre-detect the patient who will develop preeclampsia. In order to increase PE screening, it is imperative to develop a model that can predict individual PE risk. Numerous studies have investigated the association between different polymorphisms of Plasminogen activator factor-1(PAI-1) and Methylene tetrahydrofolate reductase (MTHFR) and several genes with hypertension and PE. For these reasons, it is imperative to detect risk factors and their association with preeclampsia in Egyptian women as the following : 1- Gene polymorphisms of MTHFR C677T, MTHFR A1298C and -675 4G/5G PAI-1. 2- Oxidative stress markers as SOD, GSH, GPx and MDA. To achieve this goal, this study was conducted as follows : The current study was conducted on 140 pregnant women (preeclampsia women or patient group) and healthy women (control group) were collected randomly from Obstetrics Department of Mansoura Main Hospital, Mansoura University, Egypt between 2019-2020, and blood samples from all individuals were collected from all subjects. All studied patients and control individuals were subjected to routine laboratory tests: (ALT, AST, serum albumin, serum Creatinine and random blood glucose and Complete blood count (CBC).