الفهرس 
STRIAE DISTENSAEOnly 14 pages are availabe for public view
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Abstract
SUMMARY
S
triae distensae are common skin lesions affecting up to 90% of pregnant women, and many adolescents and men. They pose a psychological burden to many people and no known treatment is completely effective for them.
Platelet-rich plasma (PRP), along with microneedling (MN), are promising dermatologic procedures with a wide range of applications, excellent safety profiles, yet only partially understood mechanisms of action. A flood of devices and methods make standardizing them into a coherent system a daunting quest.
In this study we aimed to evaluate the effectiveness of MN with PRP versus MN alone in the treatment of striae distensae. This work included 40 patients who were divided into left-side lesions (MN alone) versus right-side lesions (PRP + MN). PRP was prepared and applied topically just before MN on right-side lesions. An automated MN pen device was used on both sides.
Parameters measured to assess response were indentation index, roughness index (via Antera™ 3D camera), and patients’ self-assessed improvement and reported side effects.
Both treated sides showed a statistically significant improvement from baseline in both indentation and roughness indices, and in patient’s reported improvement of color, smoothness, size, and general appearance of lesions, but no added benefit of PRP over MN was found.
Side effects including pain and erythema affected virtually all cases, while pruritis, edema, bleeding, and tram-tracking were less common and short-lasting. Post-inflammatory hyperpigmentation affected about 20% of patients and lasted more than one month in about half of those affected.
MN is an effective, cheap, and relatively safe treatment for SD, but applied PRP had no added benefit over it.