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العنوان
A pharmacognostical study of saraca indica L. and peltophorum africanum sond.family fabaceae /
الناشر
Wedian Elsayed Mohamed Ashour ,
المؤلف
Wedian Elsayed Mohamed Ashour
هيئة الاعداد
باحث / Wedian El-Sayed Mohamed Ashour
مشرف / Seham Salah El-Din El-Hawary
مشرف / Aisha Hussein Saleh Abou Zeid
مناقش / Omar Mohamed Sabry
مناقش / Reda Sayed Mohamed
تاريخ النشر
2020
عدد الصفحات
207 P. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
العلوم الصيدلية
تاريخ الإجازة
15/11/2020
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Pharmacognosy
الفهرس
Only 14 pages are availabe for public view

from 292

from 292

Abstract

Peltophorum africanum Sond. and Saraca indica L. are plants belonging to family Fabaceae. GC/MS analysis of the volatile constituents of Saraca indica leaves revealed the identification of 19 compounds and 32 compounds of P. africanum.Analysis of the unsaponifiable fraction of the petroleum ether extract of Peltophorum africanum leaves resulted in the identification of 20 compounds .Analysis of the fatty acids of P. africanum leaves resulted in the identification of 14 compounds. Analysis of the fatty acids methyl ester of the petroleum ether extract of Saraca indica leaves resulted in the identification of of 26 compounds. Crude leaf extracts of P.africanum Sond. and S.indica L.were analyzed via reversed phase UPLC/PDA/ESI-MS in negative ionization mode Representative UPLC-MS chromatograms of P. africanum and S. indica crude extracts resulted in a total of 46 chromatographic peaks belonging to various metabolite classes were derived. UV, 1H-NMR,13C -NMR, MS spectroscopy) to identify their chemical structures. Nine compounds are isolated and identified for the first time from the leaves of P. africanum Sond. in this study and Six compounds are isolated and identified from the leaves of S.indica L. Bioactivity studies were carried out on the total ethanol and successive extracts of Peltophorum africanum Sond. and Saraca indica L . Leaves.The results of the antioxidant activity by three different methods revealed that the % scavinging activities. Investigation of the antioxidant activity of Saraca indica L. by DPPH assay revealed that there is an increase in % scavenging activity as the conc. of the plant extract increase (0.01, 0.05 g %). The TEE was the most potant extract at two selected dose levels followed by EtOAc, CHCl3 and pet.ether .Cytotoxic activity of both plants give high activity