الفهرس 
Clinicopathological characteristics of advanced non-small cell lung cancer patients with special
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Abstract
Lung cancers still the leading cause of cancer mortality worldwide. Despite the standard treatment for advanced NSCLC, the overall prognosis is very poor. Attempts to use molecular markers and detection of genetic mutations to predict the chemotherapeutic response are rapidly evolving. K-ras gene has a predictive and prognostic value in NSCLC patients. We conducted a retrospective study on 100 patients with advanced NSCLC who presented to the National cancer institute from 2010 to 2014, detection of K-ras gene mutation in tissue biopsies was done. We found that 96.2% of our patients with mutant K-ras gene were non responders (PD) while only 3.8% of patients with mutant k-ras gene were responders