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العنوان
Vectorization of anticancer compounds on a nanoparticle surface and evaluation of their anticancer potential /
الناشر
Lina Saleh Mohamed Mohamed ,
المؤلف
Lina Saleh Mohamed Mohamed
هيئة الاعداد
باحث / Lina Saleh Mohamed Mohamed
مشرف / Eman Ali Ragab
مشرف / Heba Mohamed Kamal
مشرف / Sabrein Harbi Mohamed
تاريخ النشر
2020
عدد الصفحات
127 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الكيمياء
تاريخ الإجازة
25/8/2020
مكان الإجازة
جامعة القاهرة - كلية العلوم - Biochemistry
الفهرس
Only 14 pages are availabe for public view

from 181

from 181

Abstract

Background: Super paramagnetic nanoparticle can serve as drug carrier in controlled drug delivery and targeted at cancer diagnostics and therapeutics. In this work , iron oxide nanoparticles synthesized by co-precipitation method and the conjugate was made of nanoparticles covalently bound with (Tartaric acid , Gallic acid ) through amidation after modification of nanoparticles with Carboxy methyl chitosan, the nanoparticles were characterized through(SEM, Zeta potential, XRD, and Size distribution) ,cytotoxicity effect was evaluated for acids ,bee venom, and mixtures of bee venom and acids on A549 and WI- 38 cells and their anti-cancer activities were compared , and gene expression in A549 was estimated for(Bax, P53,Bcl2) genes also