الفهرس 
Impact of sickle cell disease & its complications on pulmonary function
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Abstract
Background: Sickle cell disease is hereditary hemoglobinopathy characterized by abnormal hemoglobin production, hemolytic anemia, and intermittent occlusion of small vessels, leading to acute and chronic tissue ischemia, and organ damage. Pulmonary function tests can differentiate between obstructive or restrictive lung diseases, assess the severity of the disease and evaluate the degree of efficacy of therapy in patients with sickle cell anemia. Objective: The aim of this study was to study pulmonary function tests in children with sickle cell anemia and its correlation with iron overload. Patients and methods: This study was carried out on 100 children with sickle cell anemia under follow up at Hematology Unit, Pediatric Department, Cairo university hospitals in the period between March 2017 to March 2018 as well as 50 age- and sex-matched healthy children as a control group. The subjects included 45 SCD males and 55 SCD females with their age ranging from 5{u2013} 18 years and mean age value of 11.1±3.5 years and 50 healthy children as a control group including 25 males and 25 females with their age ranging from 5{u2013}18 years and mean age value of 11.1±1.8 years. All patients were subjected to the following investigations: Complete blood count, serum ferritin and pulmonary function tests