الفهرس 
Pattern and predictors of outcome of blood stream bacterial infections in pediatric Acute Myeloid Leukemia. (2016-2018)
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Abstract
Introduction: Children with acute myeloid leukemia (AML) are at a particularly high risk for infectious complications related to the highly intensive chemotherapy. Infections leads to mortality, prolong hospitalization, delay the administration of chemotherapy, and decrease quality of life and require the administration of costly and often toxic antimicrobial compounds. Serious infection may occur. Prompt initiation of empiric therapy can be lifesaving, so rapid evaluation is critical. Objectives: The aim of the current study is to clarify the epidemiologic characteristics of Blood stream bacterial infections, evaluate the risk factors, infectious complications and assess outcome of febrile episodes during induction and consolidation chemotherapy courses in children with AML at the Pediatric Oncology Department, National Cancer Institute, Cairo University from January 2016 to December 2018. Patients and methods: Data of 621 febrile episodes in 101 patients of pediatric Acute myeloid leukemia were retrospectively analyzed. Patients were divided into two groups, survivors and non-survivors according to outcome at end of each episode. Each febrile episode was interpreted in correlation with infectious complications.Results: 41.7% of the total studies febrile episodes were microbiologically documented. Gram negative bacteremia constitutes 26.9% of the studied episodes while gram positive bacteremia was documented in 14.9%. Mortality from gram positive bacteremia was 6.5%