الفهرس 
The effect of vitamin D deficiency on myalgia in patients on ststins
ContentsOnly 14 pages are availabe for public view
 |  | from | 115 |  |  |
| | | from | 115 | | |
Abstract
Background: There is a multitude of evidence supporting the benefit of statin use in cardiovascular disease; however, statin-induced myopathy is a major reason for statin discontinuation and non- adherence. Vitamin D deficiency has been independently associated with muscle weakness and severe myopathy, and may be a confounder for statin-induced myopathies. Objectives: To determine whether low serum vitamin D associated with the occurrence of myalgia in statin treated patients. Patients and Methods: This cross-sectional study enrolled 60 statin-treated patients to assess vitamin D status. These patients were divided into two groups: 30 patients are taking statins and have myalgia and30patients are those taking statins yet not complaining of myalgia. Results: We studied 60 statin-treated patients, which consisted of 30 patients with myalgia at study entry and 30 asymptomatic patients. All 60 patients had controlled blood pressure, normal thyroid-stimulating hormone, thyroxin, creatinine, calcium, liver enzymes and normal CK level. The 30 symptomatic and 30 asymptomatic statin-taking patients did not differ (P >0.005) at study entry by age, BMI, types of statins, type 2 diabetes mellitus, weight, height, lipid profiles and HTN duration.The mean of duration of Statin intake (months) was lower in the 30 patients with myalgia than in the 30 asymptomatic patients (4.63 ± 1.71 VS 25.63 ± 13.04, P value < 0.001)