الفهرس 
Design and evaluation of statin loaded biodegradable delivery systems to promote tissue regeneration
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Abstract
Simavstatin, lovastatin and pravastatin were found to be effective in promoting wound healing and bone regeneration. Furthermore, statins have the ability to enhance hair growth by prevention cholesterol accumulation which affects hair development. Therefore, in this thesis rosuvastatin calcium-loaded scaffolds and nanoparticles were prepared and their role in promoting wound healing and hair growth, respectively was investigated. This thesis is divided into two chapters: In chapter one the role of rosuvastatin calcium in skin regeneration was explored. Chitosan hydrochloride or sodium alginate was crosslinked with different weight ratios of collagen, Ý-glycerolphosphate and carboxymethyl cellulose to produce scaffolds by lyophilization technique. Subsequently, the fabricated scaffolds were examined for their morphology, water retention capacity, friability and in-vitro drug release as well as in-vivo studies. For the scaffolds containing chitosan hydrochloride, most of the fabricated scaffolds showed a regular 3-D shape with yellowish white spongy consistency, except those scaffolds containing Ý-glycerolphosphate as a cross-linking agent where they showed irregular surfaces and chips-like shape with non-spongy consistency. Most of the scaffolds containing sodium alginate revealed a definite round tablet-like shape except those containing Ý-glycerolphosphate and collagen where they showed an irregular fluffy shape and non-spongy consistency with off-white color and spongy consistency. The results of water retention capacity study revealed porous 3-D structured scaffolds with maximum water retention values-ranging between 179 and 2993%. Scaffolds containing carboxymethyl cellulose revealed highest water retention-valuesas selected for further investigations