الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Beta thalassemia syndromes are characterized by the presence of genetic deficiency in the synthesis of the beta globin chains which when inherited in homozygous state results in beta thalassemia major that causes severe transfusion dependent anemia.
Improved patient’s survival due advances in treatment has led to the occurrence of previously unrecognized abnormalities, such as renal disease which is the fourth cause of morbidity among β-TM patients.
Progressive tubular and glomerular injury in thalassemic patients results mainly from chronic anemia as well as hypoxia and iron overload.
Early identification of renal dysfunction using several biomarkers such as urinary β2-microglobulin helps in screening for renal dysfunction of asymptomatic β-TM patients to help intervene in a timely manner and improve the prognosis. However, further studies are required to evaluate the significance of such biomarkers.
Chronic hemolysis in β-TM patients results in a high rate of cellular turnover and therefore hyperuricemia is expected. However, there is limited data of the prevalence of hyperuricemia and its associated complications among thalassemic patients.
This case control study was conducted on 60 children with transfusion dependant beta thalassemia major attending Alexandria University Children’s Hospital and was compared with 15 apparently healthy children of matching age and sex as a control group in the period from January 2021 to June 2021. The aim of the study was to study uric acid excretion in children with beta thalassemia major and to determine if any relation is present between uric acid excretion and tubular dysfunction in these patients.
Complete physical examination and detailed history taking was done to all patients enlisted in our study, and medical records were reviewed for transfusion status and chelation therapy.