الفهرس | Only 14 pages are availabe for public view |
Abstract Cancer is an aggressive disease involving abnormal cell growth with the potential to invade other parts of the body through the blood or the lymph system. Acute myeloid leukemia (AML) is a form of cancer originated from malignant clonal stem cells in bone marrow marked by heterogenous clinical outcome due to the complexity of its molecular and cytogenetic architecture. In these regard, Gene mutations and chromosomal abnormalities are usually associated with aberrant proliferation and/or block in the normal differentiation of hematopoietic cells. So far, the combination of cytogenetic profiling and molecular and gene mutation analyses remains an essential tool for the classification, diagnosis, and treatment for AML. |