الفهرس 
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Abstract
This study was conducted in the Clinical Pathology Department and General surgery department at Assiut University Hospitals and South Egypt Cancer Institute in the period from April 2020 to April 202 The study included • group I Twenty seven patients with thyroid cancer. They included twenty two females and seven males • group II Twenty nine patients with benign thyroid diseases. They included twenty eight females and one male • group III Twenty six age and sex matched apparently healthy individuals as a control group. They included ninteen females and seven males Classification of thyroid cancer group according to TNM stagingAccording to TNM, patients in group1was classified into Stage I: This group included fourteen patients Stage II: This group included four patients Stage III: This group included nine patients. Patients and controls were subjected to the following 1- Full medical history and clinical examination and BMI was calculated 2- Fine needle aspiration biopsy (for patients only). 3- Thyroid ultrasound. 4- AJCC TNM staging was done for thyroid cancer cases Laboratory investigations A- Routine investigations ➢ Complete blood count (CBC) ➢ Blood urea nitrogen and creatinine ➢ Liver function tests ➢ TSH, Free T3 and Free TB- Special investigations: ➢ Serum midkine by ELISA ➢Relative quantitation of plasma LncRNA HOTAIR by (qRT-PCR) Results of demographic data A female predominance was found in the studied groupsBMI was significantly higher in patient with thyroid cancer than those with benign thyroid diseases and the control group.