الفهرس 
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Abstract
NHL are hematological malignancies resulting from chromosomal
alterations resulting in the uncontrolled growth of cells of lymphoid origin. BCL2
gene encode BCL2 protein family which increases the survival kinetics of the cell
specifically by blocking apoptosis. Thus it prevents the cell from going into
suicidal activities. Our study was done on 66 DLBCL cases and 40 healthy
volunteers (controls). Age and sex matched, history was taken, clinical
examination and general laboratory tests were done. By using PCR-RFLP we made
BCL2 gene polymorphism analysis.
The present study demonstrated the following results:
No statistical significant difference between cases and controls regarding
age, sex, body weight, height, systolic or diastolic blood pressure.
No statistical significant difference between cases and controls regarding
kidney or liver functions.
Hb level, WBC and platelet count were Statistically significant lower in
cases than control While Statistically significant higher results were
observed regarding Infection with virus C, LDH and B2 microglobin levels
As regards genotype assessment: c allele distribution was significantly
higher in controls than the cases while distribution of A allele was
significantly higher in cases than the control group.
By considering CC genotype is a reference genotype, both AC genotype and
AA genotype were significantly higher in patients group than the control and The risk for developing DLBCL with AA and AC genotype against CC
genotype was 4.33 time, 3.89time respectively more than CC genotype.
Regarding prognostic significance: There were no statistically significant
difference among different genotypes (AA, AC, CC) regarding B symptoms,
lymphocyte percentage in bone marrow aspirate, disease stage, extra-nodal
involvement and, beta2 micro-globulin level .
There was non-significant relation between different genotypes (AA, AC,
CC) and overall survival or relapse free survival among cases .