الفهرس 
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Abstract
The most prevalent cause of problems during pregnancy is maternal DM, which includes GDM and PGDM. Diabetes mellitus (DM) in the mother raises the possibility of CVD in her children and expectant moms. Furthermore, maternal DM is linked to a number of negative obstetric outcomes, including abnormalities, macrosomia, and newborn metabolic problems. In addition, newborn respiratory complication is a prevalent and fatal disorder. Since the early 1970s, a link has been shown between maternal DM and newborn RDS. The clinical indications of early newborn respiratory distress with consistent radiological characteristics and a need for supplementary oxygen to keep a saturation of 85 percent within the first 24 hours after delivery were used to identify neonatal RDS It is more likely than any other disease to cause morbimortality in infancy and children, and it is still a major health issue. The frequency and degree of newborn RDS are inversely related to GA at birth Neonatal RDS is caused by a pulmonary surfactant shortage, which causes immature lungs that are liable for collapsing, resulting in a functional impairment in alveolar gas exchange. In order to prevent and cure newborn RDS, several therapies have been devised, including prenatal corticosteroid injection, postnatal surfactant therapy, and mechanical ventilation. The aim of the current study was to evaluate the accuracy of foetal MPA Doppler indices in prediction of the development of neonatal RDS in diabetic mothers. This study was conducted on 100 cases of diabetic mothers in obstetrics and gynecology department, Tanta University during one year from the approval of the university counsel The study participants were then subdivided into two groups: neonates with RDS (n = 13) and the other group was neonates without RDS (n = 87). The included females were subjected to the following: History taking: Demographic data (age, gestational age and occupation) General medical history and associated comorbidities History of present pregnancy and control of diabetes Past obstetric history Menstrual history Clinical examination and general examination and regional examination Laboratory investigations: CBC, urine analysis, LFT, KFT and coagulation profile Specific investigations of diabetic profile Doppler examination of the foetal pulmonary artery. The summary of our results: NICU admission was substantially greater in RDS newborns than in non-RDS neonates (P 0.001) The neonates with RDS had substantially lower APGAR scores at 1 minute and 5 minutes than those without RDS (P0.001). Between neonates with RDS and those without RDS, EFW, BPD, HC, AC, and FL were not significantly different. P = 0.025 and 0.036, respectively, were substantially greater in neonates with RDS than in those without RDS PSV and At/Et ratio in newborns with RDS were considerably lower than in those without RDS (P = 0.004 and 0.001, respectively) The difference in S/D between newborns with RDS and those without RDS was negligible. The RI of newborns with RDS was substantially greater than that of neonates without RDS (P = 0.048) PSV and At/Et ratio were considerably lower in RDS infants than in non-RDS neonates (P = 0.008 and 0.001, respectively). With an AUC of 0.545 and P = 0.622, the cutoff value of >7 for S/D produced a sensitivity of 53.85 percent, a specificity of 60.92 percent, a PPV of 17.1 percent, and an NPV of 89.8 percent for newborn RDS prediction. With an AUC of 0.668 and P = 0.025, the cutoff value of >2 for PI produced a sensitivity of 100.0 percent, a specificity of 34.48 percent, a PPV of 18.6 percent, and an NPV of 100.0 percent for newborn RDS prediction. With an AUC of 0.655 and P = 0.152, the cutoff value of >0.87 for RI produced a sensitivity of 53.85 percent, a specificity of 89.66 percent, a PPV of 43.7 percent, and an NPV of 92.9 percent for newborn RDS prediction. With an AUC of 0.719 and P = 0.001, the cutoff value of >0.87 for PSV produced a sensitivity of 100%, a specificity of 43.68%, a PPV of 21%, and an NPV of 100% for newborn RDS prediction. With an AUC of 0.925 and P = 0.001, the cutoff value of 0.25 for At/Et ratio produced a sensitivity of 76.92%, a specificity of 100%, a PPV of 100%, and an NPV of 96.7% for newborn RDS prediction.