الفهرس 
Essential hypertensionOnly 14 pages are availabe for public view
 |  | from | 93 |  |  |
| | | from | 93 | | |
Abstract
Elevated soluble E-selectin which reflect a state of endothelial activation with subsequent vasoconstriction may elevate morning blood pressure surge. This study aimed to analyze soluble E-selectin serum concentrations in patients with essential hypertension against normotensive healthy individuals and to find a role of such molecule in the phenomenon of morning BP surge.
In this case-control study, a 24-hour ambulatory blood pressure monitoring with recording of morning BP surge and serum soluble E-Selectin levels were measured for a total 90 patients (60 patients with essential hypertension and 30 normotensive subjects as a control). The main findings in our study are the following: hypertensive patients had higher body mass index in comparison to control subjects (30.7 ± 2.3 kg/m2 versus 27 ± 3.2 kg/m2, p <0.001), serum uric acid levels were higher in hypertensive patients than control subjects (7.26 ± 2.60 mg/dl versus 5.92 ± 1.15 mg/dl, p=0.028). Hypertensive patients had higher LV mass index (110.5 ± 19.2 g/m2 versus 99.8 ± 9.5 g/m2, p=0.001). Patients with essential hypertension have higher level of soluble E-selectin than normotensive participants (180.6 ± 96.1 versus 75.9 ± 31.5 ng/ml, p<0.001). Soluble E-Selectin was positively correlated with morning BP surge (r= 0.696, P= <0.001). The conclusion of this study is patients with essential hypertension have higher level of soluble E-selectin than normotensive. Soluble E-selectin was positively correlated with morning BP surge.