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Abstract Background: Hypertrophic scar formation is a major clinical problem in the developing and industrialized worlds, Cryotherapy is the local or general use of low temperatures in medical treatment. Purpose: The purpose of the study was to evaluate the therapeutic effect of cryotherpy in treating hypertrophic scar. Subjects and methods: Sixty patients who had hypertrophic scar participated in this study.Their ages ranged from 20 to 40 years.The participants were selected from Deraya university outpatient clinic and EL Minia University Hospital, randomly distributed into two equal groups. group A (control group): This group received routine medical treatment and routine physical therapy as (Stretching exercises, Positioning and splinting, Pressure Therapy and Massage). group B (study group): This group received cryotherapy for 10 minutes at -14 degree, 2 sessions per week, for 10 weeks in addition to routine medical and physical therapy treatment. Measurements done using Matching Assessment of Scars and Photographs and was recorded in the first visit as a base line and measured another time after 3 months of treatment. Results: there was no statistically significant difference between groups regarding pretreatment data of surface, height, thickness, color, pigmentation, the total score of Matching Assessment of Scars and Photographs, there was a statistically significant difference between groups regarding post treatment data of surface, height, thickness, color, pigmentation, total score of MAPS where p value equals (0.005, 0.0001, 0.0005, 0.0021, 0.00016, < 0.00001) respectively |