الفهرس 
Histological study on the effect of rivastigmine and coconut oil on the hippocampus of experimentally induced
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Abstract
Background and objectives: Alzheimer{u2019}s disease (AD) is the most common neurodegenerative disease. This study was planned to evaluate the effect of rivastigmine and coconut oil (CO) (alone or together) on AlCl3-induced AD model in the hippocampus of adult male albino rats.Methods and Results: 33 rats were divided into control group (8rats) and experimental group: 25 rats (subdivided equally into 5 subgroups IIa, IIb, IIc, IId and IIe). Induction of AD in all experimental subgroups was done using AlCl₃ (100mg/kg/day) i.p. injection for 45 days. Subgroup IIb was left without treatment for 30 days. Subgroup IIc received rivastigmine (2.5 mg/kg/day) orally for 30 days. Subgroup IId administered CO (5g/kg/day) orally simultaneously with AlCl₃ then only the CO treatment continued for 30 days. Subgroup IIe administered CO simultaneously with AlCl₃ then treatment with CO continued simultaneously with rivastigmine for 30 days.Y-maze test was performed at the end of the experimental periods. The brain was removed and processed for biochemical and histological studies (H&E and immunohistochemical staining for glial fibrillary acidic protein (GFAP) and amyloid beta 1-42). Memory test results were improved in subgroups IIc, IId and IIe. Degenerated neurons and vacuolation of neuropil were decreased in subgroups IIc and IId while the histological picture of subgroup IIe was close to control. GFAP mean area % decreased in IIc, IId and IIe but the least was detected in IIe. Amyloid plaques decreased in IIc and IId and no plaques were detected in IIe