الفهرس 
Sensitivity and specificity of different markers of renal injury in obesity related renal disease
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Abstract
Introduction: Childhood obesity is progressively becoming an important health problem worldwide. Obesity renal disease may be asymptomatic and missed, so useful biomarkers are necessary to prevent serious renal conditions in obese children. Multiple urinary markers as KIM1, NGAL and podocalyxcin were evaluated for early diagnosis of renal injury before microalbuminuria and end-satge renal diseases. Objective: The present study was conducted to estimate and evaluate KIM-1, NGAL, and PCX as biomarkers for renal damage in obese children. Patients and methods: This cross-sectional study was carried on 120 obese children who were recruited from obesity clinic, Diabetes,Endocrine and Metabolism Pediatric Unit ,Pediatric Hospital, Cairo University, in addition to 60 age and sex matched control group. All the included obese children were subjected to full history taking, examination, and investigations including urinary microalbumin, lipid profile, complete blood picture and KIM1 level in urine. Results: There is statistically significant difference as regards urinary KIM1, NGAL, and podocalyxcin between obese cases and controls with P value =.001, Statistically significant difference between children with high KIM1 and children with normal KIM1, and children with high and normal NGAL as regards urinary micro- albumin and cholesterol level. KIM1 sensitivity is 87.5%, specificity 86.5% with P value<.001 as a marker of renal injury in obese children, NGAL had 91.7% sensitivity and 86.5% specificity in detecting kidney injury with P value <0.001 and PCX had with 83.3% sensitivity and 74% specificity for detection of kidney injury with P value <0.001