الفهرس 
Title : Protective effect of Moringa oleifera on cypermethrin-induced neurotoxicity in albino rats
العنوان العربي : التأثير الوقائى للمورينجا على السمية العصبية المستحثة للسيبرمثرين فى الجرذان البيضاءOnly 14 pages are availabe for public view
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Abstract
Introduction: Cypermethrin can cause neurotoxicity and plays a role as an inducer for mitochondrial dysfunction. The defensive capability of Moringa oleifera versus neuronal issues prompted by cypermethrin intoxication in adult male albino rats was investigated. Method: Sixty male rats were divided into six experimental groups; G1: controlled group. (G2 and G5) and (G3 and G6): the exposed groups were given high-dose (26.15 mg/kg/day representing 1/10 LD50) and low-dose (8.72 mg/kg/day representing1/30 LD50) of cypermethrin respectively by gavage. G4, G5, and G6: the treated groups were given moringa extract by gavage (250 mg/kg/day) for 14 days before starting the experiment and during it (28 days). At the end of the experiment, the rats were weighed and sacrificed then the brain of each rat was removed and weighed. The brain divided into three part. The first part of the brain for biochemical investigation, the second part for DNA fragmentation and the third part for histopathological examination. Results: The results indicated that, exposure to cypermethrin resulted in a significant reduction in the NADH dehydrogenase and ATPase in mitochondria as well as antioxidant activities (SOD, CAT, GSH, GST and GPX) and AchE enzyme activity, while the brain oxidative damage (MDA and PC), caspase-3 level and DNA fragmentation were increased significantly compared to the controlled group. The co-treatment of moringa extract alleviated the adverse effect of cypermethrin in the treated groups.Moringa declined mitochondrial dysfunction, apoptotic markers, oxidative damage (oxidant/antioxidant status) and enhanced AchE activity and histopathological changes